The Difference Between Water Based & Silicone Lubricant Kiiroo Kiiroo Amazon.com: LubeLife Barely There Thin Silicone Based Lubricant, Long Lasting, Water Resistant, Personal Lubricant for Men, Women and Couples, 8 Oz : Everything Else Vaginal Lubrication: Vaginal Dryness, Vaginal Health, and More Lube can make sex more comfortable but different types work differently for different bodies. Water based, silicone based, and oil based lubes all have their pros and cons. If something doesn't feel great Tuesday Reviews day A quick overview of lubricants Overall it really depends on the sensitivity of your tissues, whether you're using any silicone based toys and if you're using condoms.